Carey's four wins included Artist of the Year, R&B Voice of the Year, Best R&B Song for "We Belong Together" and Album of the Year for her comeback hit, The Emancipation of Mimi. She is also up for four American Music Awards, set for November 22 at the Shrine Auditorium in Los Angeles.
The night's first V trophy went to "Hate It or Love It" by The Game (featuring 50 Cent) for Hottest Hook, while hard-core rapper T.I. took home the Street Anthem award for his hit "U Don't Know Me."
Man of the hour Kanye West was named Best Rapper and newcomer Young Jeezy tied for the Next Award.
Rap artist Cam'ron and his Harlem crew the Diplomats picked up a Vibe Award for Best Group. The Reelest Video nod went to R. Kelly for his dramatic saga "Trapped in the Closet" (Chapters 1-5).
Marred last year by violence, this year's show went on without a hitch with co-hosts Tracee Ellis Ross from the sitcom Girlfriends and Anthony Anderson from the movie Hustle & Flow.
The 3rd Annual Vibe Awards will air on UPN on Tuesday, November 15 at 8pm ET/PT.